摘要
目的：探讨砷剂联合化疗治疗复发／难治多发性骨髓瘤的疗效及其应用价值。方法：32例复发／难治性多发性骨髓瘤患者分为3组，分别采用亚砷酸联合VBMCP、VAD、MOD方案。其中，亚砷酸10mg/d静脉滴注，连续10天，判断治疗效果及毒副作用。结果：亚砷酸联合化疗治疗复发／难治性多发性骨髓瘤的总有效率为81.3%，其中显效34.4%、进步46.9%；亚砷酸＋VBMCP方案有效率90％；亚砷酸＋VAD方案有效率71.4%；亚砷酸＋MOD方案有效率87.5％。长期随访10例，7例保持持续缓解状态达1年以上。主要副作用为消化道反应，其次为肝功能损害，不需停药。结论：砷剂联合化疗治疗复发／难治性多发性骨髓瘤总有效率较高，很有临床应用前景，值得推广。
关键词：多发性骨髓瘤，亚砷酸，联合化疗，难治，复发
Effect of arsenic trioxide combining with chemotherapy in treatment of relapsing and refracfory multiple myeloma
Lian Shimei, Dalian, 116023, China)
Abstract
Objective:To observe the treatment effect of relapsing and refractory multiple myeloma combining arsenic trioxide with chemotherapy. Method: 32 cases of relapsing and refractory myeloma were divided into thiry groups: arsenic trioxide + VBMCP; arsenic trioxide + VAD; arsenic trioxide + MOD. The treatment results of overall cases and each group were analyzed. Result: The efficacy rate were 81.3% in overall cases, and 90%, 71.4%, 87.5% in arsenic trioxide + VBMCP, arsenic trioxide + VAD, arsenic trioxide + MOD group, respectively. Severe side-effects were not observed in treatment. Conclusion: Arsenic trioxide combining with chemotherapy has fine efficacy in treatment of relapsing and refractory multiple myeloma.
Key words: Multiple myeloma; Arsenic trioxide; Chemotherapy; Relapse; Refractory
